{ "_id": "6a1022b0acfb0bcc41c8cd23", "Type": "Package", "Package": "gimap", "Title": "Calculate Genetic Interactions for Paired CRISPR Targets", "Version": "1.1.2", "Authors@R": "c(\nperson(\"Candace\", \"Savonen\",\nemail = c(\"cansav09@gmail.com\",\"csavonen@fredhutch.org\"), role = c(\"aut\", \"cre\")),\nperson(\"Phoebe\", \"Parrish\",\nemail = \"pcrparrish@gmail.com\", role = c(\"aut\")),\nperson(\"Kate\", \"Isaac\",\nemail = \"kisaac@fredhutch.org\", role = c(\"aut\")),\nperson(\"Howard\", \"Baek\",\nemail = \"howardbaek.fh@gmail.com\", role = c(\"aut\")),\nperson(\"Daniel\", \"Grosso\", role = c(\"aut\")),\nperson(\"Siobhan\", \"O'Brien\", role = c(\"aut\")),\nperson(\"Alice\", \"Berger\", role = c(\"aut\")))", "Author": "Candace Savonen [aut, cre], Phoebe Parrish [aut], Kate Isaac\n[aut], Howard Baek [aut], Daniel Grosso [aut], Siobhan O'Brien\n[aut], Alice Berger [aut]", "Maintainer": "Candace Savonen ", "Description": "Helps find meaningful patterns in complex genetic\nexperiments. First gimap takes data from paired CRISPR\n(Clustered regularly interspaced short palindromic repeats)\nscreens that has been pre-processed to counts table of paired\ngRNA (guide Ribonucleic Acid) reads. The input data will have\ncell counts for how well cells grow (or don't grow) when\ndifferent genes or pairs of genes are disabled. The output of\nthe 'gimap' package is genetic interaction scores which are the\ndistance between the observed CRISPR score and the expected\nCRISPR score. The expected CRISPR scores are what we expect for\nthe CRISPR values to be for two unrelated genes. The further\naway an observed CRISPR score is from its expected score the\nmore we suspect genetic interaction. 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