# -------------------------------------------- # CITATION file created with {cffr} R package # See also: https://docs.ropensci.org/cffr/ # -------------------------------------------- cff-version: 1.2.0 message: 'To cite package "gimap" in publications use:' type: software license: GPL-3.0-only title: 'gimap: Calculate Genetic Interactions for Paired CRISPR Targets' version: 1.0.2 doi: 10.32614/CRAN.package.gimap abstract: Helps find meaningful patterns in complex genetic experiments. First gimap takes data from paired CRISPR (Clustered regularly interspaced short palindromic repeats) screens that has been pre-processed to counts table of paired gRNA (guide Ribonucleic Acid) reads. The input data will have cell counts for how well cells grow (or don't grow) when different genes or pairs of genes are disabled. The output of the 'gimap' package is genetic interaction scores which are the distance between the observed CRISPR score and the expected CRISPR score. The expected CRISPR scores are what we expect for the CRISPR values to be for two unrelated genes. The further away an observed CRISPR score is from its expected score the more we suspect genetic interaction. The work in this package is based off of original research from the Alice Berger lab at Fred Hutchinson Cancer Center (2021) . authors: - family-names: Savonen given-names: Candace email: cansav09@gmail.com - family-names: Parrish given-names: Phoebe email: pcrparrish@gmail.com - family-names: Isaac given-names: Kate email: kisaac@fredhutch.org - family-names: Baek given-names: Howard email: howardbaek.fh@gmail.com - family-names: Grosso given-names: Daniel - family-names: O'Brien given-names: Siobhan - family-names: Berger given-names: Alice repository: https://fredhutch.r-universe.dev repository-code: https://github.com/FredHutch/gimap commit: 6218da3289f43fea49a3d2fbecf5b7ab9da6c28b url: https://github.com/FredHutch/gimap contact: - family-names: Savonen given-names: Candace email: cansav09@gmail.com